As in previous games, the quality of the story varies wildly, and though I don't want to spoil too much about it, they lack the charm and motivation of Handsome Jack.
Thus, a new set of four Vault Hunters are called into action by our old friend Lilith to try and stop them. Their actions have caused a cult to form, the Children of the Vault, and this new faction helps their de-facto leaders search for Vaults to open. In Borderlands 3, you'll be fighting against the Calypso Twins, a pair of jerks that have taken the bandit world by storm through livestreams of their jackassery. In Borderlands 3, Gearbox returns to the helm and has delivered a (mostly) successful sequel that improves the gameplay in meaningful ways while staying close to the formula that made the series a favorite among co-op enthusiasts.
It’s been seven years since the last proper Borderlands game was released, though a prequel and an adventure game spinoff helped fill the gap.